仿生功能材料创新团队
1. 团队简介
研究领域: 主要包括仿生化学、化学生物学、生物功能材料等。
研究方向: 仿生功能材料、先进生物医用材料、纳米生物功能材料。具体研究方向：纳米仿生功能系统的构筑；生物纳米功能材料与生物医用材料的设计与制备；光学材料与器件设计与可视化生物诊断与治疗。包括酶仿生设计与应用、光捕获系统仿生设计、仿生构筑离子通道系统、药物控释与疾病治疗、纳米生物检测与治疗、智能纳米载药系统、抗肿瘤免疫治疗。
研究团队组成: 目前团队共有8名教学科研人员，3名博士后研究人员，在读研究生30人。
实验空间及仪器设备：拥有化学合成实验室、生物合成实验室、细胞室、仪器室、设备室等实验空间。主要实验仪器包括激光共聚焦显微镜、原子力显微镜、流式细胞仪、蛋白质合成与纯化设备等。
2. 团队负责人：刘俊秋 教授
教授、博士生导师；国家“杰出青年基金”获得者；教育部“长江学者特聘教授”; 英国皇家化学学会会士(Fellow of the Royal Society of Chemistry, FRSC)；吉林省高级专家。先后主持国家重点研发计划课题、国家高技术研究发展计划(863计划)子课题、国家重点基础研究发展计划(973计划)子课题、国家自然科学基金重点项目、国家自然科学基金重点国际合作项目等。在Chem. Rev., Chem. Soc. Rev., Acc. Chem. Res., J. Am. Chem. Soc., Angew. Chem. Int. Ed.等国际知名期刊已发表SCI研究论文200余篇，主编英文专著1部，参编8部。担任J.Biomat. Nanobiotech，General Chem., Polym. Sci., 高等学校化学学报等杂志编委。任中国生物物理学会纳米酶分会副会长、中国化学会化学生物学专业委员会委员、中国生物材料学会生物医用高分子材料分会委员、吉林省化学会理事等。获得吉林省科技进步一等奖1项(第一完成人)。吉林省自然科学学术成果一等奖1项(第一完成人)。
3. 团队成员
4. 代表性成果
[1] Dingcheng Zhu, Lili Feng, Neus Feliu, Andreas H. Guse, Wolfgang J. Parak*, Stimulation of local cytosolic calcium release by photothermal heating for studying intra- and inter-cellular calcium waves. Adv. Mater., 2021, 33, 2008261 (IF: 27.398). [Link]
[2] Dongya Bai,Tengfei Yan,Shi Wang,Yanbo Wang,Jiya Fu, Xiaomin Fang,Junyan Zhu*, Junqiu Liu*. Reversible ligand‐gated ion channel via interconversion between hollow single helix and intertwined double helix. Angew. Chem. Int. Ed. 2020, 59, 13602 –13607 (IF:12.959). [Link]
[3] Hongcheng Sun*, Yan Li, Shuangjiang Yu, and Junqiu Liu*, Metal-organic frameworks (MOFs) for biopreservation: from biomacromolecules, living organisms to biological devices. Nano Today 2020, 35, 100985 (IF:16.907). [Link]
[4] Tiezheng Pan, Yao Liu, Hongcheng Sun, Jiayun Xu, and Junqiu Liu*, Reversible switch of a selenium-containing antioxidant system regulated by protein assembly. ACS Catal. 2020, 10, 17, 9735–9740 (IF:12.35). [Link]
[5] Xiumei Li, Shanpeng Qiao, Linlu Zhao, Shengda Liu, Fei Li, Feihu Yang, Quan Luo, Chunxi Hou, Jiayun Xu, Junqiu Liu*. Template-free construction of highly ordered monolayered fluorescent protein nanosheets: a bioinspired artificial light-harvesting system. ACS Nano 2019, 13, 1861-1869 (IF:14.588).[Link]
[6] Yeye Ai, Michael Ho-Yeung Chan, Alan Kwun-Wa Chan, Maggie Ng, Yongguang Li,* Vivian Wing-Wah Yam*, A Platinum(II) molecular hinge with motions visualized by phosphorescence changes, PNAS 2019, 116, 13856–13861 (IF:9.412). [Link]
[7] Shuangjiang Yu, Chao Wang, Jicheng Yu, Jinqiang Wang, Yue Lu, Yuqi Zhang, Xudong Zhang, Quanyin Hu, Wujin Sun, Chaoliang He*, Xuesi Chen* and Zhen Gu*. Injectable bioresponsive gel depot for enhanced immune checkpoint blockade. Adv. Mater. 2018, 30, e1801527. (IF: 27.39, 高被引) [Link]
[8] Chao Lang, Xiaoli Deng, Wei Wang, Shuaiwei Qi, Xin Zhang, Chenyang Zhang, Feihu Yang, Bing Yang, Zeyuan Dong*, Junqiu Liu*. Highly selective artificial potassium ion channels constructed from pore-containing helical oligomers. Angew. Chem. Int. Ed. 2017, 56,12668–12671 (IF:12.959). [Link]
[9] Yongguang Li,#* Ling Chen,# Yeye Ai, Eugene Yau-Hin Hong, Alan Kwun-Wa Chan, Vivian Wing-Wah Yam*, Supramolecular self-assembly and dual-switch vapochromic, vapoluminescent, and resistive memory behaviors of amphiphilic Platinum(II) complexes, J. Am. Chem. Soc. 2017, 139, 13858–13866 (IF:14.612). [Link]
[10] Hongcheng Sun, Quan Luo, Chunxi Hou, Junqiu Liu.* Nanostructures based on protein self-assembly: From hierarchical construction to bioinspired materials. Nano Today 2017, 14, 16-41. (IF: 16.907) [Link]
[11] Linlu Zhao, Haoyang Zou, Hao Zhang, Hongcheng Sun, Tingting Wang, Tiezheng Pan, Xiumei Li, Yushi Bai, Shanpeng Qiao, Quan Luo, Jiayun Xu, Chunxi Hou*, and Junqiu Liu*, Enzyme-triggered defined protein nanoarrays: efficient light-harvesting systems to mimic chloroplasts, ACS Nano 2017, 11, 1, 938–945 (IF:14.588). [Link]
[12] Quan Luo, Chunxi Hou, Yushi Bai, Ruibing Wang, Junqiu Liu*, Protein assembly: versatile approaches to construct highly ordered nanostructures. Chem. Rev. 2016, 116, 13571-13632 (IF: 54.301). [Link]
[13] Yushi Bai, Quan Luo, Junqiu Liu*. Protein self-assembly via supramolecular strategies. Chem. Soc. Rev. 2016, 45, 2756-2767 (IF: 40.443). [Link]
[14] Chao Lang, Wenfang Li, Zeyuan Dong,* Xin Zhang, Feihu Yang, Bing Yang, Xiaoli Deng, Chenyang Zhang, Jiayun Xu, Junqiu Liu*. Biomimetic transmembrane channels with high stability and transporting efficiency from helically folded macromolecules. Angew. Chem. Int. Ed. 2016, 128, 9875–9879 (IF:12.959). [Link]
[15] Hongcheng Sun, Xiyu Zhang, Lu Miao, Linlu Zhao, Quan Luo, Jiayun Xu and Junqiu Liu*, Micelle-induced self-assembling protein nanowires: versatile supramolecular scaffolds for designing the light-harvesting system. ACS Nano 2016, 10, 421−428 (IF:14.588). [Link]
[16] Junyan Zhu, Zeyuan Dong,* Shengbin Lei, Lili Cao, Bing Yang, Wenfang Li, Yuanchao Zhang, Junqiu Liu,* Jiacong She. Design of aromatic helical polymers for STM visualization: imaging of single and double helices with a pattern of pi–pi stacking. Angew. Chem. Int. Ed. 2015, 54, 3097-3101 (IF:12.959). [Link]
[17] Hongcheng Sun, Lu Miao, Jiaxi Li, Shuang Fu, Guo An, Chengye Si, Zeyuan Dong, Quan Luo, Shuangjiang Yu, Jiayun Xu, Junqiu Liu*. Self-assembly of cricoid proteins induced by "soft nanoparticles": an approach to design multienzyme-cooperative antioxidative systems. ACS Nano 2015, 5, 5461–5469 (IF:14.588). [Link]
[18] Chunqiu Zhang, Tiezheng Pan, Christian Salesse, Dongmei Zhang, Lu Miao, Liang Wang,Yuzhou Gao, Jiayun Xu, Zeyuan Dong, Quan Luo,* Junqiu Liu*. Reversible Ca2+ switch of an engineered allosteric antioxidant selenoenzyme. Angew. Chem. Int. Ed. 2014, 53, 13536–13539 (IF:12.959). [Link]
[19] Yuzhou Gao, Quan Luo, Shanpeng Qiao, Liang Wang, Zeyuan Dong, Jiayun Xu, Junqiu Liu*. Enzymetically regulating the self-healing of protein hydrogels with high healing efficiency. Angew. Chem. Int. Ed. 2014, 53, 9343–9346 (IF:12.959). [Link]
[20] Self-assembled peptide nanofibers designed as biological enzymes for catalyzing ester hydrolysis. ACS Nano 2014, 8, 11715–11723 (IF:14.588). [Link]
5. 奖励及荣誉
[1] 国家杰出青年科学基金（杰青）（2007）
[2] 教育部“长江学者特聘教授”奖励计划（2012）
[3] 教育部新世纪优秀人才支持计划（2004）
[4] 吉林省拔尖创新人才计划（2004）
[5] 吉林省科技进步一等奖（2009）
[6] 吉林省高级专家（2011）
[7] 吉林省自然科学学术成果一等奖（2015）
[8] 深圳市自然科学奖二等奖（2020）
[9] 广西科学技术奖三等奖（2019）
6. 主要科研项目
7. 联系方式
地 址：杭州市余杭塘路2318号杭州师范大学勤园17号楼713
电 话：+86-571-28868813（O）
E-mail：sunhc@hznu.edu.cn