【简介】祝鼎成，副教授，硕士生导师。2021.01入职杭州师范大学，加入材料与化学化工学院刘俊秋教授领导的“仿生功能材料创新团队”，担任副教授职位。入职以来共主持了3项国家、省、市级项目，入选2023年度杭州市级人才项目，2024年浙江省青年科技人才引育工程库，任2024年新质力材料发展联盟-科学家智库常务理事，是2023年“杭州市领军型创新创业团队引进培育计划”的核心成员，认定为杭州市高层次c类人才。累计在材料科学、高分子科学、医/药学、应用化学等多学科交叉的国际综合性和专业性期刊上发表论文29篇，其中以第一/通讯作者身份发表论文13篇，包括Science Advances, Advanced Materials, Advanced Functional Materials, Advanced Drug Delivery Reviews, Biomaterials, Small, Small Science等知名学术期刊。受邀在国际/国内会议上做报告5次。研究方向为研发智能响应Ca2+信号调控体系，调控细胞内离子浓度与细胞间信号通讯，用于神经调控与肿瘤治疗。
【研究方向】功能高分子；基因治疗；响应释放；钙信号通讯
【教育和工作经历】
1.2021.01-至今：杭州师范大学，材料与化学化工学院，副教授
2.2017.10-2020.12，德国汉堡大学，博士后，导师：Wolfgang Parak
3.2010.09-2017.06，浙江大学，生物化工，博士，导师：申有青
4.2006.09-2010.06，浙江大学，生物工程，学士
【荣誉与奖励】
1.2015年获得德国德意志学术交流中心Tradition-Vertrauen–Zukunft项目奖学金
【主持科研项目】
1. 主持国家自然科学基金面上基金项目，构筑高活性光催化COFs用于Ca2+介导的运动神经修复与调控 （项目编号：22475059），50万，2025.01-2028.12
2.主持国家自然科学基金青年基金项目，构筑光响应智能囊泡用于调控细胞间钙信号长程传递（项目编号：22105055），30万元，2022.01–2025.12。
3.主持浙江省基础公益研究计划，构筑光驱动智能微米马达用于调控细胞钙信号通讯（项目编号：LQ22E03001），10万元，2022.01–2025.12。
4.主持高层次留学回国人员（团队）在杭创业创新项目，构筑光响应智能囊泡用于调控细胞间钙信号长程传递（项目编号：4095C50622039），主持，18万元，2023.01-2025.12
【代表性论著】
第一/通讯作者（包括共同一作）发表论文情况：13篇
13. Yaofeng Zhou, Zherui Zhang, Chen Zhou, Yuanhong Ma, Haoye Huang, Junqiu Liu,* and Dingcheng Zhu*. Nanotechnology-Fortified Manipulation of Cell Ca2+ Signaling. Small Sci. 2024, 2400169 (IF:12.8)
12. Zherui Zhang, Yuhao Luo, Yuanhong Ma, Yaofeng Zhou, Dingcheng Zhu*, Wanhua Shen*, Junqiu Liu*. Photocatalytic manipulation of Ca2+ signaling for regulating cellular and animal behaviors via MOF-enabled H2O2 generation. Sci. Adv. 2024, 10, eadl0263. (IF: 13.6)
11. Cong Li, Yaqi Wu, Yihang Zhu, Jing Yan, Shengda Liu, Jiayun Xu, Shixin Fa, Tengfei Yan,* Dingcheng Zhu,* Yi Yan,* and Junqiu Liu*, Molecular motor-driven light-controlled logic-gated K+ channel for cancer cell apoptosis. Adv. Mater. 2024, 231252. (IF: 29.4)
10. Yaqi Wu, Cong Li, Yanliang Wu, Jiayun Xu, Zhigang Ni, Ofer Reany, Tengfei Yan,* Dingcheng Zhu,* and Junqiu Liu*. A reversible light-driven biomimetic K+/Na+-exchanger controls cancer cell apoptosis. Adv. Funct. Mater. 2024, 2400432. (IF: 19.0)
9. Dingcheng Zhu*, Huijie Yan, Yaofeng Zhou, Leroy M. Nack, Junqiu Liu, Wolfgang Parak, Design of disintegratable nanoassemblies to release multiple small-sized nanoparticles. Adv. Drug. Deliv. Rev. 2023, 197, 114854. (IF: 16.1)
8. Dingcheng Zhu, Lili Feng, Neus Feliu, Andreas H. Guse, Wolfgang J. Parak*, Stimulation of local cytosolic calcium release by photothermal heating for studying intra- and inter-cellular calcium waves. Adv. Mater. 2021, 200826. (IF: 29.4)
7. Dingcheng Zhu, Huijie Yan, Zhuxian Zhou, Jianbin Tang, Xiangrui Liu, Raimo Hartmann, Wolfgang J. Parak, Youqing Shen*, Neus Feliu*, Influence of the modulation of the protein corona on gene expression using polyethylenimine (PEI) polyplexes as delivery vehicle. Adv. Healthcare Mater., 2021, 10, e2100125 (IF: 10.0).
6. Nico Brkovic, Li Zhang, Jan N. Peters, Stephan Kleine-Doepke, Wolfgang J. Parak, Dingcheng Zhu*, Quantitative assessment of the release kinetics of various polymer-encapsulated molecular cargos by photothermal heating. SMALL, 2020, 16, 2003639 (IF: 13.3).
5. Guowei Wang,# Dingcheng Zhu# (co-first authors), Zhuxian Zhou*, Ying Piao, Jianbin Tang, Youqing Shen*, A glutathione-specific and intracellularly labile polymeric nanocarrier for efficient and safe cancer gene delivery, ACS Appl. Mater. Interfaces, 2020, 12, 14825-14838 (IF: 10.383).
4. Dingcheng Zhu, Sathi Roy, Ziyao Liu, Horst Weller, Wolfgang J Parak, Neus Feliu*, Remotely controlled opening of delivery vehicles and release of cargo by external triggers, Adv. Drug Deliv. Rev. 2019, 138, 117-132. (IF: 16.1)
3. Huijie Yan#, Dingcheng Zhu# (co-first authors), Zhuxian Zhou*, Xin Liu, Ying Piao, Zhen Zhang, Xiangrui Liu, Jianbin Tang, Youqing Shen*, Facile synthesis of semi-library of low charge density cationic polyesters from poly(alkylene maleate)s for efficient local gene delivery. Biomaterials, 2018, 178, 559-569. (IF: 14.0).
2. Dingcheng Zhu, Huijie Yan, Zhuxian Zhou, Jianbin Tang, Xiangrui Liu, Raimo Hartmann, Wolfgang J. Parak, Neus Feliu*, Youqing Shen*, Detailed investigation on how the protein corona modulates the physicochemical properties and gene delivery of polyethylenimine (PEI) polyplexes. Biomater. Sci. 2018, 6, 1800-1817. (IF: 6.6)
1. Dingcheng Zhu, Huijie Yan, Xin Liu, Jiajia Xiang, Zhuxian Zhou*, Jianbin Tang, Xiangrui Liu, Youqing Shen*, Intracellular disintegratable polysulfoniums for efficient gene delivery. Adv. Funct. Mater. 2017, 27, 1606826. (IF: 19.0)
【联系方式】zhudc@hznu.edu.cn