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祝鼎成 副教授

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【简介】工学博士,杭州师范大学副教授。已在材料科学、药学、高分子科学、应用化学、医学等多学科交叉的国际综合性和专业性期刊上发表论文25第一/通讯作者(含共同第一作者)论文9篇(8篇影响因子(IF)大于10期刊论文被SCI引用1029次,H-index16参与ACS Nano, ACS Applied Materials & Interfaces, Journal of nanobiotechnologyActa Biomaterialia等期刊的审稿。杂志Polymers的专题编辑,MDPI期刊审稿人委员会成员。参加过4次国际学术会议,并在1次国际会议上受邀做口头汇报15 min


【研究方向】功能高分子;基因治疗;响应释放;钙信号通讯


【教育和工作经历】

1.2021.01-至今:杭州师范大学,材料与化学化工学院,副教授

2.2017.10-2020.12,德国汉堡大学,博士后,导师:Wolfgang Parak

3.2010.09-2017.06,浙江大学,生物化工,博士,导师:申有青

4.2006.09-2010.06,浙江大学,生物工程,学士


荣誉与奖励

1.2015年获得德国德意志学术交流中心Tradition-Vertrauen–Zukunft项目奖学金


【主持科研项目】

1.主持国家自然科学基金青年基金项目,构筑光响应智能囊泡用于调控细胞间钙信号长程传递(项目编号:2210505530万元,2022.01–2025.12。

2.主持浙江省基础公益研究计划,构筑光驱动智能微米马达用于调控细胞钙信号通讯(项目编号:LQ22E03001,10万元,2022.01–2025.12。

3.主持高层次留学回国人员(团队)在杭创业创新项目,构筑光响应智能囊泡用于调控细胞间钙信号长程传递(项目编号:4095C50622039),主持,18万元,2023.01-2025.12


代表性论著

第一/通讯作者(包括共同一作)发表论文情况:9篇

1. Dingcheng Zhu*, Huijie Yan, Yaofeng Zhou, Leroy M. Nack, Junqiu Liu, Wolfgang Parak, Design of disintegratable nanoassemblies to release multiple small-sized nanoparticles. Adv. Drug. Deliv. Rev. 2023, (IF: 17.873)[Link] 

2.Dingcheng Zhu, Lili Feng, Neus Feliu, Andreas H. Guse, Wolfgang J. Parak*, Stimulation of local cytosolic calcium release by photothermal heating for studying intra- and inter-cellular calcium waves. Adv. Mater. 2021, 2008261 (IF: 32.086). [Link]

3. Dingcheng Zhu, Huijie Yan, Zhuxian Zhou, Jianbin Tang, Xiangrui Liu, Raimo Hartmann, Wolfgang J. Parak, Youqing Shen*, Neus Feliu*, Influence of the modulation of the protein corona on gene expression using polyethylenimine (PEI) polyplexes as delivery vehicle. Adv. Healthcare Mater., 2021, accepted (IF: 11.092)[Link]

4. Nico Brkovic, Li Zhang, Jan N. Peters, Stephan Kleine-Doepke, Wolfgang J. Parak, Dingcheng Zhu*, Quantitative assessment of the release kinetics of various polymer-encapsulated molecular cargos by photothermal heating. SMALL, 2020, 16, 2003639 (IF: 15.153). [Link]

5. Guowei Wang,# Dingcheng Zhu# (co-first authors), Zhuxian Zhou*, Ying Piao, Jianbin Tang, Youqing Shen*, A glutathione-specific and intracellularly labile polymeric nanocarrier for efficient and safe cancer gene delivery, ACS Appl. Mater. Interfaces, 2020, 12, 14825-14838 (IF: 10.383). [Link]

6. Dingcheng Zhu, Sathi Roy, Ziyao Liu, Horst Weller, Wolfgang J Parak, Neus Feliu*, Remotely controlled opening of delivery vehicles and release of cargo by external triggers, Adv. Drug Deliv. Rev. 2019, 138, 117-132 (IF: 17.873). [Link]

7. Huijie Yan#, Dingcheng Zhu# (co-first authors), Zhuxian Zhou*, Xin Liu, Ying Piao, Zhen Zhang, Xiangrui Liu, Jianbin Tang, Youqing Shen*, Facile synthesis of semi-library of low charge density cationic polyesters from poly(alkylene maleate)s for efficient local gene delivery. Biomaterials, 2018, 178, 559-569 (IF: 15.304). [Link]

8. Dingcheng Zhu, Huijie Yan, Zhuxian Zhou, Jianbin Tang, Xiangrui Liu, Raimo Hartmann, Wolfgang J. Parak, Neus Feliu*, Youqing Shen*, Detailed investigation on how the protein corona modulates the physicochemical properties and gene delivery of polyethylenimine (PEI) polyplexes. Biomater. Sci. 2018, 6, 1800-1817 (IF: 7.590). [Link]

9. Dingcheng Zhu, Huijie Yan, Xin Liu, Jiajia Xiang, Zhuxian Zhou*, Jianbin Tang, Xiangrui Liu, Youqing Shen*, Intracellular disintegratable polysulfoniums for efficient gene delivery. Adv. Funct. Mater. 2017, 27, 1606826 (IF: 19.924). [Link]



其他论文发表:16篇

1. Gan Chen, Henry Halim, Huijie Yan, Yaofeng Zhou, Dingcheng Zhu, Wolfgang J. Parak, Andreas Riedinger*, and Neus Feliu*, Semiconductor Nanoplatelets as Ultra-Bright Fluorophores for Two-Photon Absorption Cell Imaging. J. Phys. Chem. C, 2022, 126, 5658-5664 (IF: 4.177)[Link]

2. Huijie Yan, Michele Cacioppo, Saad Megahed, Francesca Arcudi, Luka Đorđević, Dingcheng Zhu, Florian Schulz, Maurizio Prato*, Wolfgang J. Parak*, Neus Feliu*. Influence of the chirality of carbon nanodots on their interaction with proteins and cells. Nat. Commun. 2021, 12, 7208 (IF: 17.694)[Link]

3. Guowei Wang, Siqin Chen, Nasha Qiu, Bihan Wu, Dingcheng Zhu, Zhuxian Zhou, Ying Piao, Jianbin Tang, Youqing Shen, Virus-mimetic DNA-ejecting polyplexes for efficient intracellular cancer gene delivery, Nano Today, 2021, 39, 101215  (IF: 18.962)[Link]

4. Carlos Sanchez-Cano, Ramon A. Alvarez-Puebla, John M. Abendroth, Tobias Beck, Robert Blick, Yuan Cao, Frank Caruso, Indranath Chakraborty, Henry N. Chapman, Chunying Chen, Bruce E. Cohen, Andre L. C. Conceição, David P. Cormode, Daxiang Cui, Kenneth A. Dawson, Gerald Falkenberg, Chunhai Fan, Neus Feliu, Mingyuan Gao, Elisabetta Gargioni, Claus-C. Glüer, Florian Grüner, Moustapha Hassan, Yong Hu, Yalan Huang, Samuel Huber, Nils Huse, Yanan Kang, Ali Khademhosseini, Thomas F. Keller, Christian Körnig, Nicholas A. Kotov, Dorota Koziej, Xing-Jie Liang, Beibei Liu, Sijin Liu, Yang Liu, Ziyao Liu, Luis M. Liz-Marzán, Xiaowei Ma, Andres Machicote, Wolfgang Maison, Adrian P. Mancuso, Saad Megahed, Bert Nickel, Ferdinand Otto, Cristina Palencia, Sakura Pascarelli, Arwen Pearson, Oula Peñate-Medina, Bing Qi, Joachim Rädler, Joseph J. Richardson, Axel Rosenhahn, Kai Rothkamm, Michael Rübhausen, Milan K. Sanyal, Raymond E. Schaak, Heinz-Peter Schlemmer, Marius Schmidt, Oliver Schmutzler, Theo Schotten, Florian Schulz, A. K. Sood, Kathryn M. Spiers, Theresa Staufer, Dominik M. Stemer, Andreas Stierle, Xing Sun, Gohar Tsakanova, Paul S. Weiss, Horst Weller, Fabian Westermeier, Ming Xu, Huijie Yan, Yuan Zeng, Ying Zhao, Yuliang Zhao, Dingcheng Zhu, Ying Zhu, and Wolfgang J. Parak*, X-ray-based techniques to study the nano-bio interface. ACS Nano, 2021, 15, 3, 3754–3807 (IF: 14.588). [Link]

5. Mikhail V. Zyuzin, Dingcheng Zhu, Wolfgang J. Parak, Neus Feliu*, Alberto Escudero*, Development of silica-based biodegradable submicrometric carriers and investigating their characteristics as in vitro delivery vehicles. Int. J. Mol. Sci. 2020, 21, 7563 (IF: 4.142). [Link]

6. Sathi Roy, Dingcheng Zhu, Wolfgang Parak, Neus Feliu*, Lysosomal proton buffering of poly(ethylenimine) measured in situ by fluorescent pH-sensor microcapsules. ACS Nano, 2020, 14, 7, 8012–8023 (IF: 14.588). [Link]

7. Ziyao Liu, Alberto Escudero, Carolina Carrillo-Carrion, Indranath Chakraborty, Dingcheng Zhu, Marta Gallego, Wolfgang J Parak, Neus Feliu*, Biodegradation of bi-labelled polymer-coated rare-earth nanoparticles in adherent cell cultures, Chem. Mater. 2020, 32, 245-254 (IF: 9.567). [Link]

8. Carolina Carrillo-Carrion, Ana I. Bocanegra, Blanca Arnaiz, Neus Feliu, Dingcheng Zhu, Wolfgang J. Parak*, Triple-labeling of polymer-coated quantum dots and adsorbed proteins for tracing their fate in cell cultures, ACS Nano, 2019, 13, 4631-4639 (IF: 14.588). [Link]

9. Shuang Zhao, Frank Caruso, Lars Dähne, Gero Decher, Bruno G De Geest, Jinchen Fan, Neus Feliu, Yury Gogotsi, Paula T Hammond, Mark C Hersam, Ali Khademhosseini, Nicholas Kotov, Stefano Leporatti, Yan Li, Fred Lisdat, Luis M Liz-Marzán, Sergio Moya, Paul Mulvaney, Andrey L Rogach, Sathi Roy, Dmitry G Shchukin, Andre G Skirtach, Molly M Stevens, Gleb B Sukhorukov, Paul S Weiss, Zhao Yue, Dingcheng Zhu, Wolfgang J Parak*, The future of layer-by-layer assembly: a tribute to ACS Nano associate editor Helmuth Möhwald, ACS Nano, 2019, 13, 6151-6169 (IF: 14.588). [Link]

10. Sathi Roy, Ziyao Liu, Xing Sun, Mustafa Gharib, Huijie Yan, Yalan Huang, Saad Megahed, Maximilian Schnabel, Dingcheng Zhu, Neus Feliu, Indranath Chakraborty, Carlos Sanchez-Cano, Alaaldin M Alkilany, Wolfgang J Parak*, Assembly and degradation of inorganic nanoparticles in biological environments, Bioconjug. Chem. 2019, 30, 2751-2762 ( IF: 4.031). [Link]

11. Jiajia Xiang, Xin Liu, Zhuxian Zhou, Dingcheng Zhu, Quan Zhou, Ying Piao, Liming Jiang, Jianbin Tang, Xiangrui Liu, Youqing Shen*, Reactive oxygen species (ROS)-responsive charge-switchable nanocarriers for gene therapy of metastatic cancer, ACS Appl. Mater. Interfaces, 2018, 10, 43352-43362 (IF: 8.758). [Link]

12. Changhuo Xu, Quan Zhou, Dingcheng Zhu, Nasha Qiu, Shiqun Shao, Xiangrui Liu, Youqing Shen*. Esterase-activated self-immolative polymericvector based on Menschutkin reaction for gene delivery. Acta Polym. Sin. 2017, 937-945 (IF: 1.801). [Link]

13. Zhuxian Zhou, Xiangrui Liu, Dingcheng Zhu, Yue Wang, Zhen Zhang, Xuefei Zhou, Nasha Qiu, Xuesi Chen and Youqing Shen*, Nonviral cancer gene therapy: delivery cascade and vector nanoproperty integration, Adv. Drug Deliv. Rev. 2017, 115, 115-154 (IF: 13.300,高被引论文). [Link]

14. Xin Liu, Jiajia Xiang, Dingcheng Zhu, Liming Jiang, Zhuxian Zhou, Jianbing Tang, Xiangrui Liu, Yongzhhuo Huang, Youqing Shen*, Fusogenic reactive oxygen species triggered charge-reversal vector for effective gene delivery. Adv. Mater. 2016, 28, 1743-1752 (IF: 27.398,高被引论文). [Link]

15. Xuefei Zhou, Xiangrui Liu*, Bingxiang Zhao, Xin Liu, Dingcheng Zhu, Nasha Qiu, Quan Zhou, Ying Piao, Zhuxian Zhou, Jianbing Tang, Jumping the nuclear envelop barrier: Improving polyplex-mediated gene transfection efficiency by a selective CDK1 inhibitor RO-3306. J. Control. Release, 2016, 234, 90-97 (IF: 7.727). [Link]

16. Yangzi Jiang, Longkun Chen, Dingcheng Zhu, Guorong Zhang, Chao Guo, Yiyin Qi, Hongwei Ouyang*, The inductive effect of bone morphogenetic protein-4 on chondral lineage differentiation and in situ cartilage repair. Tissue Eng. Part A 2010, 16, 1621-1632 (IF: 3.496). [Link]


【参与国内/国际会议情况】

1. 9th NaNax (Nanoscience with Nanocrystals international conference)(国际学术会议2019916-920,Martin-Luther-King Platz 6, 20146 Hamburg, Germany德国汉堡市。15分钟特邀口头报告:Light controlled cargo release by local photothermal heating.

2. 7th NaNax (Nanoscience with Nanocrystals international conference)国际学术会议),201644-48Biegenstrasse 10, 35037 Marburg, Germany德国马尔堡市。墙报展示Real-time eGFP expression in single cell levels after PEI-mediated gene delivery.

3. 第一届国际纳米药物大会(国际学术会议)201546-49中国浙江省杭州市滨江区六和路368号。墙报展示:Passerini reaction based parallel synthesis of degradable cationic polymer library for gene delivery. 

4. 第三届新型高分子材料与控制释放国际会议(国际学术会议)2014916-19中国江苏省苏州市沧浪区带城桥路99墙报展示Zwitterionic poly(lysine methacrylate) brush as an effective carrier for drug delivery.


【联系方式】zhudc@hznu.edu.cn




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