【简介】理学博士，杭州师范大学副教授、硕士生导师。主要从事生物医用纳米马达和人工光催化系统方面的研究。先后主持国家自然科学基金面上项目/青年项目、浙江省自然科学基金探索项目、浙江省医药卫生科技计划面上项目、高层次留学回国人员在杭创新创业项目共5项。相关研究成果发表在Angew. Chem. Int. Ed., Adv. Funct. Mater., ACS Nano, Adv. Sci.等国际知名学术期刊共发表论文60余篇，被引2000余次，个人H指数26。
【教育经历】
2007年--2011年，吉林大学，化学学院，工学学士
2011年--2016年，吉林大学，化学学院，理学博士
2016年--2018年，圣路易斯华盛顿大学，机械工程与材料科学系，博士后
2019年--2022年，杭州师范大学，材料与化学化工学院，特聘副教授
2023年-- 至 今，杭州师范大学，材料与化学化工学院，副教授
【研究方向】
1. 有机晶态多孔材料的定向设计与生物催化
致力于基于拓扑化学的晶态有机框架材料（MOF/COF/HOF）的结构设计与可控合成。通过开发系列晶态多孔材料，探究其在调控光催化活性方面的分子机制。进一步解决材料与生物活体、生物酶等之间的适配问题，构筑高效绿色生物制造体系。
2. 智能生物医用纳米材料精准构筑与疾病治疗
聚焦功能生物活体材料开发，通过结合纳米酶设计、智能马达构筑、活体疗法等概念，构筑内源性生物燃料驱动的微马达体系，探究其在细胞代谢调控、免疫微环境重塑及肿瘤精准治疗方面的潜在应用价值。
【主持或参与的科研项目】
1. 国家自然科学基金面上项目，自组装策略构筑酶驱动活体微马达用于肿瘤精准治疗，主持，50万元，2024.01-2027.12（在研）
2. 国家自然科学基金青年项目，蛋白质自组装构筑酶驱动纳米马达用于光动力抗肿瘤研究，主持，24万元，2021.01-2023.12（在研）
3. 浙江省自然科学基金探索项目，基于工程化蛋白质胶囊的酶驱动纳米马达用于增强癌症联合治疗，主持，10万元，2023.01-2025.12（在研）
4. 浙江省医药卫生科技计划项目，智能性蛋白质基生物纳米结构用于抗肿瘤治疗研究，主持，3万元，2020.01-2022.12（已结题）
5. 高层次留学回国人员（团队）在杭创业创新项目，“仿竹状”蛋白质纳米管开发抗肿瘤靶向给药系统，主持，12万元，2020.01-2022.12（已结题）
6. 杭州师范大学科研启动经费，蛋白质组装体的构建及其在仿生及生物医学的应用，主持，2019.06-2022.05（已结题）
7. 科技部重点研发计划课题，正交化蛋白质元件的组装应用，骨干参与，335万元，2021.01-2025.12（在研）
8. 国家自然科学基金国际（地区）合作项目，基于竹环构筑选择性氯离子转运体和通道，骨干参与，200万元，2022.01-2024.12（已结题）
9. 杭州市领军型创新创业团队，酶仿生功能材料创新创业团队，骨干参与，500万元，2023.01-2025.12（在研）
10. 杭州师范大学交叉创新团队项目，多层次手性材料的精准构筑及其诊疗研究，骨干参与，2024.05-2028.04（在研）
11. 国家自然科学基金面上项目，构筑蛋白质基超分子聚合物模拟光捕获系统，参与，65万元，2016.01-2019.12（已结题）
【代表性论著】（第一作者或通讯作者论文）
27. Xiaoqian Shi#, Yan Li#, Yuancheng Ji, Shuangjiang Yu, Junqiu Liu*, Hongcheng Sun*. Molecular engineering of covalent organic frameworks for boosting carbon dioxide photoreduction via modulating carrier dissociation and transfer. Chem. Eng. J. 2025, 507, 160346. [Link]
26. Yan Li, Jieqiong Wang, Xiaoqian Shi, Xiaoxuan Yu, Shuangjiang Yu, Junqiu Liu*, Hongcheng Sun*. Spatiotemporal Encapsulation of Tandem Enzymes in Hierarchical Metal–Organic Frameworks for Cofactor-Dependent Photoenzymatic CO2 Conversion. Adv. Sci. 2024, 11, 2410024. [Link]
25. Xiaoxuan Yu, Hui Li, Chengchen Xu, Zhengwei Xu, Shuheng Chen, Wang Liu, Tianlong Zhang, Hongcheng Sun*, Yan Ge*, Zhenhui Qi*, Junqiu Liu*. Liquid–Liquid Phase Separation-Mediated Photocatalytic Subcellular Hybrid System for Highly Efficient Hydrogen Production. Adv. Sci. 2024, 11, 2400097. [Link]
24. Hui Li, Xiaoxuan Yu, Yaqi Wu, Cong Li, Zhengwei Xu, Wang Liu, Shuheng Chen, Hongcheng Sun*, Yan Ge*, Zhenhui Qi*, Junqiu Liu*. Membraneless organelles assembled by AuNPs-enzyme integration in non-photosynthetic bacteria: Achieving high specificity and selectivity for solar hydrogen production. Chem. Eng. J. 2024, 492, 152207. [Link]
23.Yuwei Gao#, Yan Li#, Xuesha Yan, Yan Zhu, Zhengwei Xu, You Xu, Shuangjiang Yu, Junhua Wan*, Junqiu Liu*, and Hongcheng Sun*. NIR-II light-powered core-shell prodrug nanomotors enhance cancer therapy through synergistic oxidative stress-photothermo modulation. Acta Biomater. 2024, 185, 396-409. [Link]
22. Zhengwei Xu, Xiaoxuan Yu, Fan Gao, Mingsong Zang, Liwei Huang, Wang Liu, Jiayun Xu, Shuangjiang Yu, Tingting Wang, Hongcheng Sun*, Junqiu Liu*. Fighting bacteria with bacteria: A biocompatible living hydrogel patch for combating bacterial infections and promoting wound healing. Acta Biomater. 2024, 181, 176-187. [Link]
21. Hui Li, Xiaoxuan Yu, Yao Qin, Tao Jiang, Jijun Wang, Zhongqi Cai, Jiayun Xu, Yan Ge*, Hongcheng Sun*, Zhenhui Qi*, Junqiu Liu*. Synergistic Approaches for Enhanced Light-Driven Hydrogen Production: A Membrane-Anchoring Protein-Engineered Biohybrid System with Dual Photosensitizers Strategy. ACS Mater. Lett. 2024, 6, 1418-1428. [Link]
20. Yuwei Gao#, Yan Li#, Zhengwei Xu#, Shuangjiang Yu, Junqiu Liu*, Hongcheng Sun*. Multiporphyrinic architectures: Advances in structural design for photodynamic therapy. Aggregate 2024, 5, e420. [Link]
19. Jieyu Yu#, Yan Li#, An Yan#, Yuwei Gao, Fei Xiao, Zhengwei Xu, Jiayun Xu, Shuangjiang Yu, Junqiu Liu*, Hongcheng Sun*. Self-Propelled Enzymatic Nanomotors from Prodrug-Skeletal Zeolitic Imidazolate Frameworks for Boosting Multimodel Cancer Therapy Efficiency. Adv. Sci. 2023, 10, 2301919. [Link]
18. Mingsong Zang, Yuancheng Ji, Xiaoran Ding, Zhengwei Xu, Jinxing Hou, Jianxin Sun, Jiayun Xu, Shuangjiang Yu*, Hongcheng Sun*, Tingting Wang*, Junqiu Liu*. Trojan nanobacteria hybridized with prodrug nanocapsules for efficient combined tumor therapy. Nano Res. 2023, 16, 9651-9662. [Link]
17. Yan Li*, Aowei Zhao, Jieqiong Wang, Jieyu Yu, Fei Xiao and Hongcheng Sun*. Highly Bright Gold Nanowires Arrays for Sensitive Detection of Urea and Urease. Nanomaterials 2022, 12, 4023. [Link]
16. Tengfei Yan, Shengda Liu, Cong Li, Jiayun Xu, Shuangjiang Yu, Tingting Wang*, Hongcheng Sun*, Junqiu Liu*. Flexible Single-Chain-Heteropolymer-Derived Transmembrane Ion Channels with High K+ Selectivity and Tunable pH-Gated Characteristics. Angew. Chem. Int. Ed. 2022, 61, e202210214. [Link]
15. Ruizhen Tian, Hongyin Ma, Wei Ye, Yijia Li, Shiping Wang, Zherui Zhang, Shengda Liu, Mingsong Zang, Jinxing Hou, Jiayun Xu, Quan Luo, Hongcheng Sun*, Fuquan Bai*, Yi Yang*, Junqiu Liu*. Se-Containing MOF Coated Dual-Fe-Atom Nanozymes With Multi-Enzyme Cascade Activities Protect Against Cerebral Ischemic Reperfusion Injury. Adv. Funct. Mater. 2022, 32, 2204025. [Link]
14. Yijia Li, Chunlei Xia, Ruizhen Tian, Linlu Zhao, Jinxing Hou, Jieqiong Wang, Quan Luo, Jiayun Xu, Liang Wang, Chunxi Hou, Bai Yang, Hongcheng Sun*, Junqiu Liu*. "On/Off" Switchable Sequential Light-Harvesting Systems Based on Controllable Protein Nanosheets for Regulation of Photocatalysis. ACS Nano 2022, 16, 8012-8021. [Link]
13. Jieqiong Wang, Fei Li, Zhengwei Xu, Mingsong Zang, Shengda Liu, Tianhe Li, Jiayun Xu, Hongcheng Sun*, Shuangjiang Yu*, Junqiu Liu*. Bacteria-triggered radical anions amplifier of pillar[5]arene/perylene diimide nanosheets with highly selective antibacterial activity. Chem. Eng. J. 2022, 444, 136620. [Link]
12. Shengda Liu, Shanpeng Qiao, Tengfei Yan, Xiumei Li, Shuangjiang Yu, Hongcheng Sun*, Jiayun Xu, Junqiu Liu*. Giant nanotubes equipped with horseradish peroxidase active sites: a powerful nanozyme co-assembled from supramolecular amphiphiles for glucose detection. Chem. Eng. J. 2022, 429, 132592. [Link]
11. Tengfei Yan, Shengda Liu, Jiayun Xu, Hongcheng Sun*, Shuangjiang Yu*, Junqiu Liu*. Unimolecular Helix-Based Transmembrane Nanochannel with a Smallest Luminal Cavity of 1 Å Expressing High Proton Selectivity and Transport Activity. Nano Letters 2022, 21, 10462-10468. [Link]
10. Shengda Liu, Jiayun Xu, Yunpeng Xing, Tengfei Yan, Shuangjiang Yu, Hongcheng Sun*, Junqiu Liu*. Nanozymes as efficient tools for catalytic therapeutics. View 2022, 3 (2), 20200147. [Link]
9. Yuancheng Ji, Jiayun Xu, Hongcheng Sun*, Junqiu Liu*. Artificial photosynthesis (AP): From molecular catalysts to heterogeneous materials. Chem. Res. Chinese U. 2022, 38 (3), 688-697. [Link]
8. Shengda Liu, Jiayun Xu, Xiumei Li, Tengfei Yan, Shuangjiang Yu, Hongcheng Sun*, Junqiu Liu*. Template-free self-assembly of two-dimensional polymers into nano/microstructured materials. Molecules 2021, 26 (11), 3310. [Link]
7. Hongcheng Sun*, Yan Li, Shuangjiang Yu, and Junqiu Liu.* Metal-organic frameworks (MOFs) for biopreservation: From biomacromolecules, living organisms to biological devices. Nano Today 2020, 35, 100985. [Link]
6. Hongcheng Sun, Yan Li, Shuangjiang Yu and Junqiu Liu*. Hierarchical Self-Assembly of Proteins Through Rationally Designed Supramolecular Interfaces. Front. Bioeng. Biotechnol. 2020, 8:295. [Link]
5. Hongcheng Sun, Quan Luo, Chunxi Hou, and Junqiu Liu.* Protein self-assembly nanostructures: From hierarchical construction to bioinspired materials. Nano Today 2017, 14, 16-41.[Link]
4. Hongcheng Sun, Xiyu Zhang, Lu Miao, Linlu Zhao, Quan Luo, Jiayun Xu, and Junqiu Liu.* Micelle-induced self-assembling protein nanowires: versatile molecular scaffolds for designing the light-harvesting system. ACS Nano 2016, 10, 421-428. [Link]
3. Hongcheng Sun, Linlu Zhao, Tingting Wang, Guo An, Shuang Fu, Xiumei Li, Xiaoli Deng, Junqiu Liu. Photocontrolled reversible morphology conversion of protein nanowires mediated by an azobenzene-cored dendrimer. Chem. Commun. 2016, 52, 6001-6004. [Link]
2. Hongcheng Sun, Lu Miao, Jiaxi Li, Shuang Fu, Guo An, Chengye Si, Zeyuan Dong, Quan Luo, Shuangjiang Yu, and Junqiu Liu.* Self-assembly of cricoid proteins induced by “soft nanoparticles”: an approach to design multienzyme-cooperative antioxidative systems. ACS Nano 2015, 9, 5461-5469. [Link]
1. Hongcheng Sun, Gang Zhang, Zhongguo Liu, Na Zhang, Liyuan Zhang, Wenjia Ma, Chengji Zhao, Duo Qi, Guibin Li, Hui Na. Self-crosslinked alkaline electrolyte membranes based on quaternary ammonium poly (ether sulfone) for high-performance alkaline fuel cells. Int. J. Hydro. Energy 2012, 37, 9873-9881. [Link]
【专利授权】
1. 孙鸿程，余婕妤，李艳，于双江，刘俊秋，一种兼具化疗及光动力联合疗效的共价铂药/卟啉囊泡及其构筑方法和应用，授权日期：2023.09.26，专利号：ZL202211123557.5
2. Shuangjiang Yu, An Yan, Shu Wei, Hongcheng Sun, Junqiu Liu, Cis-Plantinumcross-linked protein hydrogel and preparation method thereof, 授权日期：2024.07.30，专利号：US 12048715B2
3. 于双江，闫安，魏舒，孙鸿程，刘俊秋，一种顺铂交联的蛋白水凝胶及制备方法，授权日期：2023.04.28，专利号：ZL 202111279597.4
4. 刘俊秋，张哲瑞，田瑞桢，于双江，孙鸿程，一种含硒咪唑配合物纳米微球及其制备方法和应用，授权日期：2023.07.18，专利号：ZL 202111388323.9
【指导研究生情况】
2025级硕士研究生：苏琼，戚春宇，杨阳
2024级硕士研究生：严雪莎，祝雁，朱桢康
2023级硕士研究生：肖飞，施笑千
2022级硕士研究生：高俞炜（校优秀毕业生，校优秀毕业论文）
2021级硕士研究生：王洁琼（校优秀毕业生），余婕妤（校优秀毕业论文）
【联系方式】0571-28868813 sunhc@hznu.edu.cn
【通讯地址】浙江省杭州市余杭区杭州师范大学勤园17号楼713