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团队负责人:刘俊秋 教授

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【简介】

教授、博士生导师;国家杰出青年基金获得者;教育部长江学者特聘教授;英国皇家化学学会会士(Fellow of the Royal Society of Chemistry, FRSC);吉林省高级专家。先后主持国家重点研发计划课题、国家高技术研究发展计划(863计划)子课题、国家重点基础研究发展计划(973计划)子课题、国家自然科学基金重点项目、国家自然科学基金重点国际合作等项目。在Chem. Rev., Chem. Soc. Rev., Acc. Chem. Res., J. Am. Chem. Soc., Angew. Chem. Int. Ed.等国际知名期刊已发表SCI研究论文200余篇,主编英文专著1部,参编8部。担任J.Biomat. NanobiotechGeneral Chem., Polym. Sci., 高等学校化学学报等杂志编委。任中国生物物理学会纳米酶分会副会长、中国化学会化学生物学专业委员会委员、中国生物材料学会生物医用高分子材料分会委员、吉林省化学会理事等。获得吉林省科技进步一等奖1(第一完成人)。吉林省自然科学学术成果一等奖1(第一完成人)


【研究方向】

主要从事仿生化学、化学生物学、纳米生物功能材料等方面的研究。


【教育经历】

1983.09-1987.07 吉林大学 高分子化学与物理专业 本科

1987.07-1990.09 吉林大学 高分子化学与物理专业 硕士

1996.07-1999.12 吉林大学 高分子化学与物理专业 博士

2001.12-2003.09 海涅杜塞尔多夫大学 高分子化学 博士后


荣誉与奖励

1.   国家杰出青年科学基金(杰青)(2007

2.   教育部长江学者特聘教授奖励计划(2012

3.   教育部新世纪优秀人才支持计划(2004

4.   吉林省拔尖创新人才计划(2004

5.   吉林省科技进步一等奖(2009

6.   吉林省高级专家(2011

7.   吉林省自然科学学术成果一等奖(2015

8.   深圳市自然科学奖二等奖(2020

9.   广西科学技术奖三等奖(2019


【主持或参与的科研项目】

1. 国家重点研发计划课题,正交化蛋白质元件的组装应用,主持,335万元,执行时间:2021-2025

2. 国家杰出青年科学基金,高分子仿酶研究,主持,200万元,执行时间:2008-2011。

3. 教育部长江学者奖励计划,主持,200万元,执行时间:2012-2017。

4.国际(地区)合作交流项目,超分子组装构建智能蛋白质组装体,主持,240万元,执行时间:2015-2019。

5. 国家自然科学基金重点项目,组合分子印迹与自组装构筑高效仿酶体系, 主持,310万元,执行时间:2013-2017。

6. 国家自然科学基金重点项目,高效抗氧化酶的分子设计及其药学研究,主持,160万元,执行时间:2006-2009。

7. 国家高技术研究发展计划(863计划)子课题 含硒抗体酶的分子改造及药学研究,主持,210万元,执行时间:2001-2005。

8. 国家重点基础研究发展计划(973计划)子课题,分子自组装与组装体的功能:生物膜模拟与人工酶,主持,100万元,执行时间:2007-2011。

9. 国家自然科学基金委重大研究计划培育项目,蛋白质自组装及组装体结构调控与功能集成构筑,主持,110万元,执行时间:2011-2013。

10. 国家自然科学基金面上项目,蛋白质基超分子聚合物模拟光捕获系统,主持,65万元,执行时间:2016-2019。


代表性论著

1. Dongya Bai,Tengfei Yan,Shi Wang,Yanbo Wang,Jiya Fu, Xiaomin Fang,Junyan Zhu*, Junqiu Liu*. Reversible ligand‐gated ion channel via interconversion between hollow single helix and intertwined double helix. Angew. Chem. Int. Ed. 2020, 59, 13602 –13607. [Link]

2. Xiumei Li, Shanpeng Qiao, Linlu Zhao, Shengda Liu, Fei Li, Feihu Yang, Quan Luo, Chunxi Hou, Jiayun Xu, Junqiu Liu*. Template-free construction of highly ordered monolayered fluorescent protein nanosheets: a bioinspired artificial light-harvesting system. ACS Nano 2019, 13, 1861-1869.[Link]

3. Hongcheng Sun, Quan Luo, Chunxi Hou, Junqiu Liu.* Nanostructures based on protein self-assembly: from hierarchical construction to bioinspired materials. Nano Today 2017, 14, 16-41. [Link]

4. Chao Lang, Xiaoli Deng, Wei Wang, Shuaiwei Qi, Xin Zhang, Chenyang Zhang, Feihu Yang, Bing Yang, Zeyuan Dong*, Junqiu Liu*. Highly selective artificial potassium ion channels constructed from pore-containing helical oligomers. Angew. Chem. Int. Ed. 2017, 56,12668 –12671. [Link]

5. Quan Luo,Chunxi Hou,Yushi Bai,Ruibing Wang, Junqiu Liu*, Protein assembly: versatile approaches to construct highly ordered nanostructures. Chem. Rev. 2016, 116, 13571-13632. [Link]

6. Yushi Bai, Quan Luo, Junqiu Liu*. Protein self-assembly via supramolecular strategies. Chem. Soc. Rev., 2016, 45, 2756-2767. [Link]

7. Hongcheng Sun, Xiyu Zhang, Lu Miao, Linlu Zhao, Quan Luo, Jiayun Xu and Junqiu Liu*. Micelle-induced self-assembling protein nanowires: versatile supramolecular scaffolds for designing the light-harvesting system. ACS Nano 2016, 10, 421−428. [Link]

8. Chao Lang, Wenfang Li, Zeyuan Dong,* Xin Zhang, Feihu Yang, Bing Yang, Xiaoli Deng, Chenyang Zhang, Jiayun Xu, Junqiu Liu*. Biomimetic transmembrane channels with high stability and transporting efficiency from helically folded macromolecules. Angew. Chem. Int. Ed. 2016, 128, 9875 –9879. [Link]

9. Junyan Zhu, Zeyuan Dong,* Shengbin Lei, Lili Cao, Bing Yang, Wenfang Li, Yuanchao Zhang, Junqiu Liu,* Jiacong She. Design of aromatic helical polymers for STM visualization: imaging of single and double helices with a pattern of pi–pi stacking. Angew. Chem. Int. Ed. 2015, 54, 3097-3101. [Link]

10. Hongcheng Sun, Lu Miao, Jiaxi Li, Shuang Fu, Guo An, Chengye Si, Zeyuan Dong, Quan Luo, Shuangjiang Yu, Jiayun Xu, Junqiu Liu*. Self-assembly of cricoid proteins induced by "soft nanoparticles": an approach to design multienzyme-cooperative antioxidative systems. ACS Nano 2015, 9, 5461-5469. [Link]

11. Chunqiu Zhang, Tiezheng Pan, Christian Salesse, Dongmei Zhang, Lu Miao, Liang Wang,Yuzhou Gao, Jiayun Xu, Zeyuan Dong, Quan Luo,* Junqiu Liu*. Reversible Ca2+ switch of an engineered allosteric antioxidant selenoenzyme. Angew. Chem. Int. Ed. 2014, 53, 13536–13539. [Link]

12. Yuzhou Gao, Quan Luo, Shanpeng Qiao, Liang Wang, Zeyuan Dong, Jiayun Xu, Junqiu Liu*. Enzymetically regulating the self-healing of protein hydrogels with high healing efficiency. Angew. Chem. Int. Ed. 2014, 53, 9343 –9346. [Link]

13. Chunqiu Zhang, Xiangdong Xue, Quan Luo, Yiwei Li, Keni Yang, Xiaoxi Zhuang, Yonggang Jiang, Jinchao Zhang, Junqiu Liu*, Guozhang Zou,*Xing-Jie Liang*. Self-assembled peptide nanofibers designed as biological enzymes for catalyzing ester hydrolysis. ACS Nano 2014, 8, 11715–11723. [Link]

14. Lu Miao, Jishu Han, Hao Zhang, Linlu Zhao, Chengye Si, Xiyu Zhang, Chunxi Hou, Quan Luo, Jiayun Xu, Junqiu Liu*. Quantum-dot-induced self-assembly of cricoid protein for light harvesting. ACS Nano 2014 8, 3743–3751. [Link]

15. Chunxi Hou, Jiaxi Li, Linlu Zhao, Wei Zhang, Quan Luo, Zeyuan Dong, Jiayun Xu, and Junqiu Liu*. Construction of protein nanowires through Cucurbit[8]uril-based highly specific host–guest interactions: an approach to the assembly of functional proteins. Angew. Chem. Int. Ed. 2013, 52, 5590–5593. [Link]

16. Yushi Bai, Quan Luo, Wei Zhang, Lu Miao, Jiayun Xu, Hongbin Li, Junqiu Liu*. Highly ordered protein nanorings designed by accurate control of glutathione S‑transferase self-assembly. J. Am. Chem. Soc. 2013, 135, 10966−10969. [Link]

17. G Wulff*, Junqiu Liu*, Design of biomimetic catalysts by molecular imprinting in synthetic polymers. Acc. Chem. Res. 2012,45,239-248. [Link]

18. Zeyuan Dong, Quan Luo, Junqiu Liu*. Artificial enzymes based on supramolecular scaffolds. Chem. Soc. Rev., 2012, 41, 7890-7908. [Link]

19. Xin Huang, Xiaoman Liu, Quan Luo, Junqiu Liu*, Jiacong Shen. Artificial selenoenzymes: designed and redesigned. Chem. Soc. Rev. 2011, 40, 1171-1184. [Link]

20. Chunxi Hou, Quan Luo, Jinliang Liu, Lu Miao, Chunqiu Zhang, Yuzhou Gao,Xiyu Zhang,Jiayun Xu, Zeyuan Dong, Junqiu Liu*. Construction of GPx active centers on natural protein nanodisk/nanotube: a new way to develop artificial nanoenzyme. ACS Nano 2012, 6, 8692–8701. [Link]

21. Yong Tang, Lipeng Zhou, Jiaxi Li, Quan Luo, Xin Huang, Ping Wu, Yongguo Wang, Jiayun XuJiacong Shen, Junqiu Liu*. Giant nanotubes loading artificial peroxidase centers: self-assembly of supramolecular amphiphiles as a tool to functionalize nanotubes. Angew. Chem. Int. Ed. 2010, 49, 3920-3924. [Link]

22. Xiaoman Liu, Silks Louis A., Liu Cuiping, Ollivault–Shiflett Morgane, Huang Xin, Jing Li, Luo Guomin, Hou Ya-Ming, Junqiu Liu*, Shen Jiacong. Incorporation of tellurocysteine into glutathione transferase installs high glutathione peroxidase efficiency. Angew. Chem. Int. Ed. 2009,48,2020-2023. [Link]

23. Junqiu Liu*, Guenter Wulff*, Functional mimicry of carboxypeptidase A by a combination of transition state stabilization and a defined orientation of catalytic moieties in molecularly imprinted polymers. J. Am. Chem. Soc.  2008, 130, 8044-8054. [Link]

24. Sizong Mao, Zeyuan Dong, Junqiu Liu*, Xiaoman Liu, Guimin Luo, Jacong Shen. Semisynthetic tellurosubtilisin with glutathione peroxidase activity. J. Am. Chem. Soc. 2005, 127, 11588-11589. [Link]

25. Zeyuan Dong, Junqiu Liu*, Sizhong Mao, Xin Huang , Bing Yang, Ren XJ, Luo GM, Jicong Shen. Aryl thiol substrate 3-carboxy-4-nitrobenzenethiol strongly stimulating thiol peroxidase activity of glutathione peroxidase mimic 2,2´-ditellurobis (2-deoxy-β-cyclodextrin). J. Am. Chem. Soc. 2004, 126, 16395-16404. [Link]

26. Xi Zhang*. Huping Xu, Zeyuan Dong, Yapei Wang. Junqiu Liu*. Jiacong Shen. Highly efficient dendrimer-based mimic of glutathione peroxidase. J. Am. Chem. Soc. 2004, 126, 10556-10557. [Link]

27. Book Ed. By Liu Junqiu, Guimin Luo and Ying Mu. Selenoproteins and Mimics. Springs-ZJUP. 2011. 398 pages.


【参与国内/国际会议情况】

1. The 23rd IUPAC International Conference on Physical Organic Chemistry (ICPOC23). July 3-8, 2016, Sydney, Australia. (Keynote Talk)

2. The 251st ACS National Meeting & Exposition. Mar. 13-17, 2016, San Diego, USA. (Invited Ta

3. The 1st EMN Meeting on Carbon Nanostructures. Mar. 27 -31 Hawaii, USA. (Invited Talk)

4. 6th Jilin-Korea-Waseda Alliance Annual Symposium on “Supramolecular and Functional Materials”. Aug. 19, 2016, Changchun China. (Invited Talk)

5. The International Conference on Scanning Probe Microscopy on Soft and Polymeric Materials 2016. Aug. 26-29, 2016.Changchun, China. (Invited Talk)

6. The 7th International Symposium on Polymer Chemistry (PC2016), Sept. 7- 10, 2016. Changchun, China. (Invited Talk)

7. The International Conference on Advanced Functional Materials 2016. Nov. 25-26, 2016, Shenzhen,China (Invited Talk)

8. The 7th International Conference on Nanoscience & Technology (ChinaNANO 2017). Aug. 29-31, 2017, Beijing, China. (Invited Talk)

9. The 5th International Conference on Cucurbituril (ICCB2017). Jun. 27-30, 2017, Brno, Czech. (Invited Talk)

10. The National Polymer Academic Meeting. Oct. 10-15, 2017, Chengdu, Sichuan, China. (Invited Talk)

11. The 10th National Conference on Chemical Biology. Sept.23-26, 2017, Wuhan, China. (Invited Talk)

12. International Symposium on Supramolecular Chemistry 2017 (ISSC-2017). Sep.17-19, 2017. Changchun, China. (Invited Talk)

13. The 31st Annual Conference of the Chinese Chemical Society. May 5-8, 2018, Hangzhou, China. (Invited Talk)

14. The Symposium on Colloid and Interface Chemistry. 2018, April 25-26, 2018, Beijing, China. (Invited Talk)

15. The 8th International Symposium on Polymer Chemistry (PC2018). Jun. 6-9,2018, Changchun, China. (Invited Talk)

16. The International Symposium on Polymer Liquid Crystal and Supramolecular Structures 2018, Aug. 7-10, 2018, Qingdao, China. (Invited Talk)

17. The 19th National Symposium on Supramolecular Chemistry (2018MCSM). Aug. 16-19, 2018. Inner Mongolia, China. (Plenary Talk)

18. The International Peptide Self-Assembly Conference 2018. Aug. 24-26, Beijing, China. (Invited Talk)

19. International Supramolecular System Symposium 2018 (SSS2018). Aug.27-28, 2018, Changchun, China. (Invited Talk)

20. The Polymer Biomaterials Summit forum. Dec. 11-13, 2018, Shenzhen, China (Invited Talk)

21. The International Symposium on Soft Matter Science and Technology 2018. Nov. 3-6, 2018, Chengdu, China. (Invited Talk)

22. The 4th Youth Polymer Forum of Shaanxi Chemical Society, Dec. 26-28, 2018, Xi 'an, China. (Invited Talk)

23. Biomedical Polymer Materials Conference and Cross-Strait Academic Exchange Conference 2019. April 18-20, 2019, Nanjing, China. (Invited Talk)

24. The 17th Chinese and International Biophysics Conference, Aug. 2-5, 2019, Tianjin, China. (Invited Talk)

25. The 8th International Conference on Nanoscience & Technology (China NANO 2019). Beijing, China, Aug.17-19, 2019. (Invited Talk)

26. The 1st National Cellulose Symposium of the Chinese Chemical Society. Oct. 10-13 2019, Chengdu, China. (Invited Talk)

27. The National Polymer Academic Report Conference2019. Xi 'an, China. Oct. 15-19, 2019. (Invited Talk)

28. The 11th National Conference of Chemical Biology. Nov. 18, 2019, Guangzhou, China. (Invited Talk)

29. Westlake University Academic Exchange. 2020, Nov, 10-11, Hangzhou, China (Invited Lecture)

30. The 4th JiangNan Polymer Materials Forum. Nov.12-14, 2020.Wuxi, China (Invited Talk)

31. The 14th "Feng Xinde Polymer Prize" Report. Nov. 23-27, 2020. Changchun, China. (Invited Talk)

32. Supramolecular Chemistry Kageng Forum. Xiamen,China. Jan. 8-9, 2021. (Invited Talk)


【专利申请与授权】


1. 罗贵民、刘俊秋、任晓君、阎岗林、牟颖、杨同书、沈家骢,含硒环糊精在制备治疗白内障药物中的应用,中国发明专利,授权日期:2004.02.04,专利号:ZL00133040.3

2. 俞慧君、罗贵民、刘俊秋、任晓君、沈家骢,硒代木瓜蛋白酶的制备,中国发明专利,授权日期:2005.10.26,专利号:ZL110835.0

3. 罗贵民、阎岗林、贾志丹、牟颖、任晓君、刘俊秋、张鲲、沈家骢,环糊精衍生物的药物用途及其药物组合物,中国发明专利,授权日期:2006.02.15,专利号:ZL05119443.5

4.李飞、付爽、刘俊秋,一种兼具选择性及光热抗菌性能的纳米片层、制备方法及其应用,中国发明专利,申请日期:2021.05.04,专利申请号:202010557811.7







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